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The Globe's Macbeth - Millson and Spiro head cast

Samantha Spiro as Dolly Levi in Hello, Dolly! at the Open Air theatre. Photograph: Catherine Ashmore.

Preview by Lizzie Guilfoyle

JOSEPH Millson (in the title role) and double Olivier award-winner Samantha Spiro (as Lady Macbeth) will lead the cast of Eve Best’s production of Macbeth, which runs at Shakespeare’s Globe between June 22 and September 29, 2013.

The Porter will be played by celebrated cabaret artist Bette Bourne.

When three witches tell Macbeth that he is destined to occupy the throne of Scotland, he and his wife choose to become the instruments of their fate and to kill the first man standing in their path, the virtuous King Duncan.

But to maintain his position, Macbeth must keep on killing – first Banquo, his old comrade-in-arms; then, as the atmosphere of guilt and paranoia thickens, anyone who seems to threaten his tyrant’s crown.

Joseph Millson’s theatre credits include Every Good Boy Deserves Favour and Pillars of the Community (National Theatre); Fear and Misery and The Priory (Royal Court Theatre); Cinderella (Old Vic); numerous productions for the Royal Shakespeare Company including Much Ado About Nothing, King John and The God in the Manger; Judgment Day (Almeida Theatre) and Love Never Dies (Adelphi Theatre).

On screen, Millson is best known as Sam Morgan in Peak Practice, Jason James in EastEnders and Luc Hemingway in Holby City. His other screen credits include Ashes to Ashes, Survivors, New Tricks, The Sarah Jane Adventures, Casino Royale and Telstar.

Samantha Spiro returns to Shakespeare’s Globe having played Katherina in their 2012 production of The Taming of the Shrew. Her extensive stage credits also include Filumena (Almeida Theatre), Chicken Soup with Barley (Royal Court Theatre), her Olivier Award-winning performance in Hello Dolly (Regent’s Park Open Air Theatre), Twelfth Night and Merrily We Roll Along, for which she received her first Olivier (Donmar/West End).

Bette Bourne previously appeared at the Globe in 2004 as the Nurse in Romeo and Juliet. His varied career includes performing as Quentin Crisp in Resident Alien at the Bush and on tour, as himself in the biographical A Life in Three Acts (Traverse Theatre, Edinburgh) and as Pauncefort Quentin in The Vortex at the Donmar Warehouse, for which he won a Clarence Derwent Award.

Macbeth will be directed by stage and screen actress Eve Best who makes her directorial debut at the helm of the Scottish play. Best won great acclaim for her performance as Beatrice in the Globe’s 2011 production of Much Ado About Nothing.

Macbeth will be designed by Mike Britten and composed by Olly Fox.

Public booking for the 2013 theatre season is now open. Tickets are available through the box office: 020 7401 9919 or online at www.shakespearesglobe.com.